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All living systems perpetuate themselves via growth in or on the body, followed by splitting, budding, or birth. We find that synthetic multicellular assemblies can also replicate kinematically by moving and compressing dissociated cells in their environment into functional self-copies. This form of perpetuation, previously unseen in any organism, arises spontaneously over days rather than evolving over millennia. We also show how artificial intelligence methods can design assemblies that postpone loss of replicative ability and perform useful work as a side effect of replication. This suggests other unique and useful phenotypes can be rapidly reached from wild-type organisms without selection or genetic engineering, thereby broadening our understanding of the conditions under which replication arises, phenotypic plasticity, and how useful replicative machines may be realized. 

Robot swarms have, to date, been constructed from artificial materials. Motile biological constructs have been created from muscle cells grown on precisely shaped scaffolds. However, the exploitation of emergent self-organization and functional plasticity into a self-directed living machine has remained a major challenge. We report here a method for generation of in vitro biological robots from frog ( Xenopus laevis ) cells. These xenobots exhibit coordinated locomotion via cilia present on their surface. These cilia arise through normal tissue patterning and do not require complicated construction methods or genomic editing, making production amenable to high-throughput projects. The biological robots arise by cellular self-organization and do not require scaffolds or microprinting; the amphibian cells are highly amenable to surgical, genetic, chemical, and optical stimulation during the self-assembly process. We show that the xenobots can navigate aqueous environments in diverse ways, heal after damage, and show emergent group behaviors. We constructed a computational model to predict useful collective behaviors that can be elicited from a xenobot swarm. In addition, we provide proof of principle for a writable molecular memory using a photoconvertible protein that can record exposure to a specific wavelength of light. Together, these results introduce a platform that can be used to study many aspects of self-assembly, swarm behavior, and synthetic bioengineering, as well as provide versatile, soft-body living machines for numerous practical applications in biomedicine and the environment. 

Catastrophic forgetting continues to severely restrict the learnability of controllers suitable for multiple task environments. Efforts to combat catastrophic forgetting reported in the literature to date have focused on how control systems can be updated more rapidly, hastening their adjustment from good initial settings to new environments, or more circumspectly, suppressing their ability to overfit to any one environment. When using robots, the environment includes the robot's own body, its shape and material properties, and how its actuators and sensors are distributed along its mechanical structure. Here we demonstrate for the first time how one such design decision (sensor placement) can alter the landscape of the loss function itself, either expanding or shrinking the weight manifolds containing suitable controllers for each individual task, thus increasing or decreasing their probability of overlap across tasks, and thus reducing or inducing the potential for catastrophic forgetting. 

A robot's mechanical parts routinely wear out from normal functioning and can be lost to injury. For autonomous robots operating in isolated or hostile environments, repair from a human operator is often not possible. Thus, much work has sought to automate damage recovery in robots. However, every case reported in the literature to date has accepted the damaged mechanical structure as fixed, and focused on learning new ways to control it. Here we show for the first time a robot that automatically recovers from unexpected damage by deforming its resting mechanical structure without changing its control policy. We found that, especially in the case of "deep insult", such as removal of all four of the robot's legs, the damaged machine evolves shape changes that not only recover the original level of function (locomotion) as before, but can in fact surpass the original level of performance (speed). This suggests that shape change, instead of control readaptation, may be a better method to recover function after damage in some cases. 

Abstract One of the key differentiators between biological and artificial systems is the dynamic plasticity of living tissues, enabling adaptation to different environmental conditions, tasks, or damage by reconfiguring physical structure and behavioral control policies. Lack of dynamic plasticity is a significant limitation for artificial systems that must robustly operate in the natural world. Recently, researchers have begun to leverage insights from regenerating and metamorphosing organisms, designing robots capable of editing their own structure to more efficiently perform tasks under changing demands and creating new algorithms to control these changing anatomies. Here, an overview of the literature related to robots that change shape to enhance and expand their functionality is presented. Related grand challenges, including shape sensing, finding, and changing, which rely on innovations in multifunctional materials, distributed actuation and sensing, and somatic control to enable next‐generation shape changing robots are also discussed.